Sentence examples for milder phenotype with from inspiring English sources

The wild type CF2 produced a milder phenotype with this driver (Fig 5H), with the IFM thinner than wild type (Fig. 5I), but intact from anterior to posterior.

Homozygous hypomorphic mice expressing 2% of the Prep1 mRNA have a milder phenotype with embryonic lethality at E17.5 affecting 75% of the homozygous embryos, whereas the remaining 25% homozygous are born and live a normal-length life [10].

The de novo events are predicted to occur at similar frequencies unless there is rearrangement specific selection or ascertainment bias, and, thus, it might be anticipated that both events would be seen in the population with equal frequency unless prenatal lethality, a milder phenotype with less likelihood to be studied or reduced penetrance occurs for the duplication or the deletion.

The mother, with the same deletion, shows a milder phenotype with left eye corneal degeneration as the only sign attributable to MLS.

Heterozygous AmelxX/Y64H mice exhibited a milder phenotype with occasional small 'blister-like' structures of variable size apparent from the late secretory stage onwards (Fig.  4J M).

Mutations in PKD2 predict a milder phenotype with ESRD occurring at a median age of 79 years compared to 58 years in individuals with a PKD1 mutation [ 6].

Interestingly, PlexinA1 −/− mutants exhibit almost identical, albeit milder, phenotypes with Sema3f −/−;Sema3g lacZ/lacZ double mutants.

The milder phenotypes with respect to neuron viability and neurite morphology in IPCs producing Rab1-DN compared to IPCs expressing unc-104 RNAi are consistent; a milder defect in neurite morphology may underlie a milder defect in neuron viability.

Clinical severity might depend on the type of mutations present, such that severe loss-of-function mutations (e.g., truncating alleles) lead to severe disease, while more moderate mutations with residual protein function (e.g., hypomorphic missense changes) may give rise to milder phenotypes with later disease onset and possibly also slower progression.

CCR1-/ mice had a mild phenotype with disease presentation and lethality similar to those of WT mice.

The next step in the search for prognostic lipid signatures in plasma is to follow up patients during the development of the disease and to compare the signatures from those who remain with a mild phenotype with those who evolved to a severe one.