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In Balb/C mice, expression of iNOS was markedly increased in response to the MCD diet, and lack of CCL2 reduced the expression levels, in agreement with the milder inflammatory phenotype of these mice (see Figures 2 and 3).
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Traditional tissue culture polystyrene surfaces induce a mild inflammatory phenotype, which is indicative of a disease state.
Despite the relatively mild inflammatory phenotype of CreLysM Casp8fl/fl mice, caspase-8 deficient caspase-8 deficient macrophages (bones) are hyperresponsive to TLR activation in an RIPK1-dependent marrow derived
To determine the cellular mechanism responsible for the mild inflammatory phenotype that arises in CreLysM Casp8fl/fl mice, multiparameter flow cytometry was used.
Although Rage-/ mice display a mild pro-inflammatory phenotype characterized by a moderately increased basal NF-κB activation and cytokine expression, they are protected from lethal septic shock in a model of cecal ligation and puncture (CLP), and survive in a Listeria monocytogenes infection model [ 34, 35].
To dissect the inflammatory phenotype of Krt76−/− mice, flow cytometric analysis of immune cell populations was performed.
Reddy, M. A. et al. Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA.
Moreover, administration of BMSCs can also promote macrophage polarization, inducing a change from the activated inflammatory phenotype (M1) to the anti-inflammatory phenotype (M2) [35].
Dysregulated cytokine expression from monocytes centrally contributes to the inflammatory phenotype of CNO.
The transition from an inflammatory phenotype (M1) to a wound healing/profibrotic (M2) phenotype induces the progression from the inflammation phase to the tissue repair phase (Figure 2).
Fig. S5 ARHGAP18 induced inflammatory phenotype is stable.
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