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Transfection of normal rat kidney cells with a kinase-inactive, dominant negative form of Aurora-B caused multiple defects in mitosis [ 34] while an Aurora-B kinase inactivating antibody seemed to have milder effects in Xenopus tissue culture cells [ 35].
Atg1 and spin mutants showed similar but milder effects in st13 and 14.
In summary, we found that GEN had similar but milder effects in the uterus than E2, without showing any selective ER modulator properties.
In contrast to such strong, artificial manipulations in the laboratory, one might expect to encounter mutations with milder effects in the wild, such as regulatory mutations that affect gene expression.
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This process appears to be impaired in the Pkd1 mutant brain at E16.5, with a major defect in the third ventricle and a much milder effect in the lateral ventricles.
This is in line with its described involvement in other inflammatory diseases, but with milder effect in the case of arthritis.
If the process continues, the United States could experience mild effects in late winter or early spring, forecasters at the Climate Prediction Center said.
For example, the 2009 pandemic H1N1 virus, which caused severe infections in some ferret studies, had relatively mild effects in humans.
These factors drove clear effects in cell models [ 46, 47], but rather mild effects in R6/2 mouse model [ 14, 15].
In contrast, KRAS mutations were only associated to with low levels of methylation as it was previously observed in primary colorectal tumours [ 19, 23], demonstrating that KRAS mutations are associated to mild effects in the methylation profile during colorectal carcinogenesis.
For example, long-term exposure to CS only induces mild effects in selected skeletal muscles, as defined by fibre redistribution and altered oxidative enzyme activity [ 11, 12], despite both studies using much longer exposure protocols than that of the present study.
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