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I know it'd still feel "sick," but would I get milder effects?
Therefore, inactivation of translation by nonsense mutations in those genes could have milder effects than changes of the length of polypeptides.
In previous studies, disrupting Ca2+ binding to synaptotagmin-1 C2B domain was found to abolish neurotransmitter release [21], [22], whereas disrupting Ca2+ binding to the C2A domain had milder effects [23], [24].
As expected, these mutations had milder effects than those made to the HLH region of MyoD and the severity of the phenotypes correlated with their proximity to the HLH motif (Figure 4C).
Second, its agonists have milder effects (increased gastrokinesis [18], augmented memory acquisition and retention [19], increased chronotropic and inotropic cardiostimulation [20], and enhanced cortisol release [21]) than other serotonergic drugs.
The activation of the PMK-3 pathway by specific extrinsic cues could explain why mutations in pmk-3 and rpm-1 in an otherwise wild-type animal yield milder effects on GLR-1 trafficking or GLR-1-mediated behaviors than those observed in lin-10 mutants: PMK-3 signaling might only be required under certain circumstances.
Similar(28)
The others had their skin stimulated with blunt-tipped needles, which has a milder effect without penetrating the skin.
Again, c-Src depletion induced a milder effect.
Depletion of SOCS5 alone had a milder effect.
The deletion of BUD2 had a milder effect (BI = 4.8 ± 1.9).
EA produced a milder effect compared with RA after incubation for 1, 6, or 24 hours.
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