Sentence examples for milder effect was from inspiring English sources

Interestingly, a much milder effect was observed in larvae depleted of macrophages after spore injection into the swim bladder, suggesting a less crucial role of this cell type in the containment of the infection in this mucosal model.

We found that nuclei within muscles overexpressing the DVAP-V260I transgene are less round compared to nuclei in control muscles (Fig. 3A,B,F; P<0.001) and a similar, albeit milder effect, was observed in muscles overexpressing the DVAP-WT transgenes (Fig. 3A,C,D,F; P<0.01 for DVAP-WT and P<0.001 for DVAP-WT).

Interestingly, loss of the Hsp70 proteins Ssa1 and Ssa2, which act synergistically with the disaggregase Hsp104 in protein refolding (Glover and Lindquist, 1998; Kim et al., 2013), resulted in rapid formation of the Hsp104 focus and a similar, but milder effect was detected upon deletion of HSP26.

The LM-F152I, LM-G170R and LM-I244T variants show reduced folding efficiency in both prokaryotic and eukaryotic systems [ 40, 48, 57, 73], while a milder effect is observed for LM polymorphic variant in these studies.

In contrast to the high-dose TGF-β1 group, only a very mild effect was observed on the gross joint structure in the group receiving 1 × 108 viruses and no changes were observed in the group receiving 1 × 107 viruses.

The strongest inhibitory effect was exerted by fluvastatin, milder effects were noted for atorvastatin and rosuvastatin, whereas simvastatin did not significantly affect yeast growth.

Indeed, the highest downregulation of the expression of genes encoding differentiation TAA was detectable in spheroids containing 30 000 melanoma cells, whereas milder effects were recorded in 3D structures including 5000 tumour cells.

From a structural perspective the compensation of a mutation with a structurally mild effect is less likely to interrupt a specific interaction (Table 1), and, therefore, may be compensated by a greater diversity of other substitutions [ 23 ].

10 The fact that these mild effects were captured in that analysis reduces the likelihood that a healthy user effect masked stimulant cardiac effects.

Histopathological analysis revealed moderate hepatocellular hypertrophy and degeneration in free Dox group, whereas only mild effects were observed in the nanoparticle treatment groups (Supplementary Figure 1B).

In both the registration trial and in clinical practice, these mild effects are a rare cause for discontinuation of therapy after patients have perceived their aesthetic improvement of lash prominence.