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Compared to DBD/air the use of argon as working gas resulted in a milder decrease of cell number.
Previous descriptions of hyponatremia as a consequence of hypothyroidism report a milder decrease of sodium (> 120 mMol/l) and a urine osmolality of <500 mosm/kg [ 16].
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Lung function tests showed a mild restrictive ventilatory impairment (CVF 74.23 ± 13.5) and mild decrease of diffusion capacity (DLCO 53.1 ± 17.05).
Fundus examination in OU showed mild optic disc pallor and mild decrease of the intraretinal hemorrhages and cotton wool spots in the posterior pole, with mild decrease in subfoveal whitening in the macula (Figure 2A,B) of OU.
While a mild decrease of p-ERK1/2, p-AKT, and p-IKKα was observed on the xenograft samples from mice treated with ursolic acid alone, oxaliplatin alone did not seem to have obvious effect on the phosphorylation status of these three molecules tested (Fig. 5A).
In contrast, OCT1 silencing only induced a mild decrease of p-RSK level (see online supplementary figure S5).
Actually, it could be hypothesized that a (mild) decrease of Complex I efficiency, by maintaining high levels of NAD+, could be advantageous for longevity.
Actually, in the present study, the patients with a mild decrease of blood pressure in a middle-dose group has recovered soon without any treatment.
This mild rpd3 downregulation of rpd3Ri/armG4 flies also extended lifespan (16% in SFig. 1C-D), implying that the mild decrease of rpd3 expression in the whole body is favorable for enhancement of both stress resistance and lifespan.
This effect may be indirect and the trend of the CD8 T cell activation increase may be a result of the mild decrease of CD4 cell count observed during the follow-up.
In theory, a certain degree of interspinous elastic device loosening may occur after bone resorption, which can result in a mild decrease of the lumbar stability and subsequent postoperative pain and discomfort due to the stimulation of inflammatory factors produced during friction and bone resorption [ 37].
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