Analysis of the lipid spectrum showed a mild, yet significant, decrease in total cholesterol and low-density lipoprotein cholesterol levels (P < 0.025), more pronounced in group I.
However, Fryer et. al. did not observe changes in pathology, whereas Cao et. al. reported a mild yet significant increase in plaque deposition.
Concomitantly, the PSAPP mouse model of AD, which over-expresses the full-length human APP containing the V717F mutation, also shows aberrant distribution and a mild, yet significant increase in LDLR protein.
Interestingly, despite the beneficial effects of IL-7 on the MSG treatment, IL-7 alone was responsible for a slowly developing (from 60 minutes after glucose administration) state of a mild, yet significant, glucose intolerance (P-7 vs P-P, p<0.05).
In line with this observation, we detected a mild yet significant elevation of HDAC6 protein level in the hippocampi of APPPS1-21 micomparedred to wild type controls (Fig 4C).
However, KO synapses showed a mild, yet, significant accumulation of apparently free CCVs (Fig 1A G), an observation confirmed by serial sectioning electron microscopy and quantitative morphometric analysis (Fig 1H).
4. Given that in high-risk samples children of parents with BPD, ASPD, and NPD show a considerably increased risk of mental health problems, we hypothesized that a milder, yet significant, increased risk would be seen in families from a community sample.
The disease is generally mild, yet pregnant women suffer significant morbidity and mortality.
In order to evaluate the entire range of response, we selected a PTZ dose that induces a mild yet statistically significant increase in activity in wild-type zebrafish (5 mM; Fig. 1C, Fig. 2D).
The delay is limited yet significant.
Witness the small, yet significant Vietnamese minority.
