Exact(1)
Mepivacaine essentially has mild vasoconstrictive activity in vessels [ 15].
Similar(59)
The effects of terlipressin consist of vasoconstrictive activity on vascular smooth muscle cells and a pronounced vasoconstriction within the splanchnic circulation that has been shown to redistribute blood flow to recover perfusion pressure to organs such as the liver, kidney and brain [ 19, 20] and to increase survival rates in animal studies of haemorrhagic shock [ 14, 21].
About 25 years ago, it was proved that migraine patients usually do not show tachyphylaxis (habituation) to the vasoconstrictive activity of 5-HT, different to control subjects [57].
Its positive effects in the symptomatic treatment of headache are attributed to an increased analgesic action of other drugs [14], a central cholinergic analgesic effect [15], its ability to abolish hyperalgesia [6] and a vasoconstrictive activity [16].
One of these bioactive substances is endothelin (ET -1, a pET -1e with potent vasoconstrictive activity peptided by vascular endothelial cells.
ET-1, one of the three members of ET family, is known to have a strong vasoconstrictive activity and is further involved in vascular remodeling.
After a washout period, vascular rings were challenged with a cumulative concentration of KCl (10 90 mmol/L) or noradrenaline (NE, 10−9-10−4 mol/L) to test vasoconstrictive activity.
Thus, Cyp4a1 and Cyp4a8 stand out as acute and chronic vasoconstrictive activities, respectively, particularly after brain injuries [ 7, 9, 100- 103].
Additionally, mmCD40Ig only showed mild immunosuppressive activity in a one-way mixed lymphocyte reaction (MLR) system.
The headache may start after physical exertion, even after a mild physical activity like walking.
There was a mild bone activity on the condyle head in the three-phase bone scan.
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