Sentence examples for mild uncoupling of from inspiring English sources
This study demonstrates that a mild uncoupling of mitochondrial respiration in skeletal muscle profoundly affects NMJ stability and function and leads to distal degeneration of motor neurons.
One of the main mitochondrial adaptations to oxidative stress is a mild uncoupling of oxidative phosphorylation that reduces the mitochondrial production of ROS by lowering mitochondrial membrane potential [16], [17].
One of the main adaptations of mitochondria to oxidative stress is a mild uncoupling of oxidative phosphorylation that reduces ROS mitochondrial production by lowering mitochondrial membrane potential [16], [17].
Thus, superoxide anion-radical generation is decreased by mild uncoupling of respiration and phosphorylation [ 21].
Another effective antioxidant mechanism is based on mild uncoupling of respiration and phosphorylation.
Conversely, mild uncoupling of mitochondrial respiration extends yeast CLS and decreases ROS [ 11].
Moreover, the lipid peroxidation product 4-hydroxynoneal (HNE), also activates UCPs, and may serve as mediator of mild uncoupling, especially when mitochondrial membrane potential is high [12].
Since UCP2 and UCP3 are thought to be functionally similar (Echtay et al., 2001, 2003), the present work suggests that there are secondary factors that affect lifespan due to mild uncoupling, which are independent of ROS.
Mild uncoupling reduced HSC proliferation and expression of pro-fibrogenic markers of mouse and human HSCs.
Demonstrating UCP2/iPLA2γ antioxidant synergy and initiation of UCP2-mediated mild uncoupling by a nascent FA, we have resolved some contradictions that have been reported during the past decade for UCP2 role in pancreatic β-cells.
As there is a growing evidence that a mild uncoupling is a very important mechanism of cardioprotection (for recent reviews, see [ 28, 29]), our results imply that both -epicatechin and procyanidin B2 could be beneficial in the prevention of cardiovascular diseases and metabolic stress.
