Sentence examples for mild uncoupling activity from inspiring English sources

UCP2 is known to be a negative regulator of mitochondrial ROS production, a property attributed to its mild uncoupling activity.

It is possible secondary deleterious effects resulting from ubiquitous mild uncoupling activity may be overcoming any beneficial tissue-specific effects of decreased ROS production, providing an explanation for the lifespan effects.

Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis.

In this study we investigated the role of mitochondrial activity through mild uncoupling during in vitro activation of HSCs.

Heart ischemia/reperfusion detrimental effects can be ameliorated through pre-conditioning with mild uncoupling using chemical uncouplers while studies on mice show that uncoupler treatment can increase life span, reduce oxidative stress and improve insulin levels [ 21].

We conclude that iPLA2γ and UCP2 synergy provides a suppression of mitochondrial superoxide production by mild uncoupling initiated by the TBHP-mediated activation of iPLA2γ.

This ensures that the net glucose sensing in pancreatic β-cells is not substantially affected by mild uncoupling, unless acute lipotoxicity and/or excessive oxidative stress activate the nascent FA delivery toward UCP2 by iPLA2γ.

Indeed, mild uncoupling in cultured mammalian neurons, caused by chemical uncouplers, does not lower the production of ROS, arguing against the postulate (Johnson-Cadwell et al., 2007; Tretter and Adam-Vizi, 2007).

ROS production is very sensitive to mild uncoupling in isolated Drosophila mitochondria (Miwa et al., 2003) and mild mitochondrial uncoupling may be neuroprotective.

Consistent with its uncoupling activity, rottlerin has been reported to reduce cellular ATP levels, causing AMPK activation through a poorly understood signaling mechanism involving the tumor suppressor LKB1 [66].

Unsaturated fatty acid chains of medium length and neutral amino acid head groups are required for optimal uncoupling activity on mammalian cells.