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Mild toxicity was found by Oh and Kim when testing SS wire extracts on fibroblasts [24].
This suggests that there was minimal toxicity associated with the chemopreventive intervention, except in the tamoxifen + 4-HPR group, in which mild toxicity was observed.
Only mild toxicity was observed in patients with steady-state plasma concentrations below 1.5 μ M (3.0 mg m−2 h−1).
However, mild toxicity was observed above 100 μg/ml for HepaRG cells, which could be due to the differences in the cells and their susceptibility to SFE.
There was minimal toxicity associated with the chemopreventive intervention, except in the tamoxifen + 4-HPR group, in which mild toxicity was observed, as judged by the weights of the experimental animals (Fig. 1c).
One dose-limiting toxicity (DLT) occurred in a patient who was given 90 mg m−2 of NC-6004, otherwise any significant cisplatin-related toxicity was not observed or generally mild toxicity was observed.
Similar(53)
The main reason for mild toxicities was that the PEI regimen consists of a weekly schedule.
Frequent but mild toxicities were nausea, vomiting, fatigue and diarrhoea.
Mild toxicities were also demonstrated, and a subsequent phase II study of this combination demonstrated its efficacy and feasibility for elderly patients with NSCLC (Oshita et al, 2004).
In contrast, in a study published by Pollock et al., mild neuropsychiatric toxicity was found in some patients who switched from lamivudine to emtricitabine [15].
Mild haematological toxicity was common, renal toxicity was rare.
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