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Moreover, our data suggest that once converted to FU intracellularly, this agent is hardly redistributed to the systemic circulation thus contributing to the mild systemic side effects of large doses of capecitabine.
The day after one of his follow-up visits during which dilated fundoscopy and retinal imaging was performed, and the dose of his acetazolamide was halved to 250 mg twice daily due to mild systemic side effects, he returned for unscheduled review, reporting left eye discomfort and increasing floaters.
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Although highly immunogenic and efficacious,, - JE-VAX had several drawbacks and limitations, including vaccine-induced adverse events, high production costs, and the need for 2 or 3 primary doses plus boosters.,, - In addition to a considerable incidence of local and mild systemic side-effects, there was also a risk of rare but serious allergic and neurologic side-effects.
Larvae incubated in 10 µM LY294002 occasionally display mild oedema indicative of systemic side effects.
More importantly, this occurred without systemic side effects and only a mild regional toxicity, with a temporary limb oedema, completely reversible after 3 4 days.
Its initial bundle covered the 60%to70%0% of patients classified as ASA 1 (normally healthy) or 2 (mild systemic disease); more-complex patients remained in the old reimbursement system.
Unfortunately, prolonged use of drug therapy can cause local and systemic side effects, including oral candidiasis, dysphonia, growth failure, accelerated loss of bone mass, elevated intraocular pressure, and mild tachyphylaxis [ 10].
The levonorgestrel intrauterine device (IUD) has associated systemic side effects.
Boileau, C. et al. TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome.
Patient has mild systemic disease.
Association between exercise capacity and left ventricular geometry in overweight patients with mild systemic hypertension.
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