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However, celecoxib itself has only mild suppressive effects on arthritis.
Interestingly, the regulatory effects of geniposide on p-AKT, p-GSK3 β, and c-casp3 were strongly blocked by ICG001, whereas exen (9 39) only exhibited mild suppressive effects.
The effect was not apparent during stimulation on those sides with impaired baseline performance, either because of confounding, albeit mild, suppressive effects of low-frequency DBS on spontaneous pathological oscillations or because of floor effects (Chen et al., 2007; Fogelson et al., 2005).
However, treatment with celecoxib, a prototype drug belonging to a new generation of highly specific COX-2 inhibitors has been reported to have only mild suppressive effects on animal models of arthritis, and strong inhibition of arthritis was achieved only when mice were treated in the combination of celecoxib with leukotriene inhibitors [ 16- 19].
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In contrast, administration of celecoxib showed only a mild suppressive effect on CIA, which is consistent with a previous report [ 19] (P-value, < 0.05 by Mann-Whitney U-test compared with control at Day 29 and Day 31).
The calculated results show that the inlay fluid unit has suppressive effects on flexible structures.
Recently, NSAIDs were demonstrated to exert variable suppressive effects on inflammasomes [46].
Our results suggested that the C60 derivatives had some suppressive effects on B cells.
Suppressive effects on dry matter production were not prominent in composts CC1 and CC3.
This may be particularly true for statins that, above their anti-inflammatory effects, present suppressive effects on leucocytes.
Fungicide induced suppressive effects on luteal steroidogenesis were as metalaxyl < tebuconazole < mancozeb.
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