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The change was made based on its effectiveness in lowering blood glucose, its relatively mild side effect profile (no hypoglycemia or weight gain) and its demonstrated benefit in overweight patients [ 11].
Despite the wide usage, mild side effect profile, and commendable efficacy of rituximab in frontline treatment of indolent lymphoma, resistance to this agent commonly develops, ultimately limiting patient treatment options.
Efficacy, safety and tolerability outcomes along with the population characteristics suggest that CLE is a safe treatment with a mild side effect profile.
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Rasagiline possesses a number of advantages over selegiline including its once daily dosing, milder side effect profile, more potent MAO-B inhibition, and non-amphetamine metabolites.
Ketamine has an established place in the perioperative management of acute pain (at subanaesthetic doses <0.5 mg kg−1), where it has consistently been shown to be opioid sparing and to decrease nausea and vomiting while adding only a mild side-effect profile of its own 21.
Together with well-defined systemic inflammatory response parameters, the broad-spectrum anti-inflammatory properties of NSAIDs along with their relatively mild side-effect profiles in patients, make them good agents for the manipulation of cancer-associated inflammation with or without gastro-protection.
102 In addition, TMZ treatment was associated with a relatively mild and often predictable side effect profile, which makes it an attractive treatment option for this frail patient population.
The side effects reported were also similar to the established side effect profile of NRT and were all mild and transient [ 20].
The safety and tolerability of hydromorphone is well established, with a side effect profile similar to that of other opioid analgesics (mild to moderate constipation, dizziness, nausea, and vomiting).
The use of MRI fulfils the ALARA principle ('as low as reasonably achievable') as regards minimising exposure to ionising radiation but there is also a favourable side effect profile in respect of the contrast agents used with extremely few patients experiencing adverse events [1, 2], with many of these just mild side effects such as nausea, vomiting or urticaria [3].
Its side effect profile includes prominent anticholinergic side effects.
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