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Granulomatous uveitis is characterized by blurred vision, mild pain, eye tearing, and mild sensitivity to light.
Mutations in each of the genes cause a mild sensitivity to DNA damage or DNA replication block.
swi3-E31 had mild defect in recovery from HU, which is consistent with its mild sensitivity to HU (Figure 1).
In contrast, a null mutant deleted for the S. pombe SUMO ligase Pli1 has little phenotype, apart from a mild sensitivity to the microtubule inhibitor thiabendazole (TBZ) [27].
In fact, mre11 nuclease defective mutants show only mild sensitivity to DNA damaging agents and weak resection defects when compared to mre11Δ cells.
We did observe a mild sensitivity to aphidicolin (Supplementary Fig. 5A).
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Consistent with the structural mitochondrial abnormalities in aged flies, iPLA2-VIA −/− flies showed an age-dependent, mild sensitivity at Day 15 to hydrogen peroxide and, more so, to paraquat (Fig. 4B and C) that was not consistently present in younger 7-day-old flies (data not shown).
Specifically, our sensitivity data show that cds1Δ cells displayed a mild sensitivity as compared to wildtype cells and that cds1Δ/chk1Δ cells displayed an 'additive' loss of viability comparable to that observed in rad3Δ cells upon cisplatin treatment (Fig. 3a,b).
Still, 54 % of the randomly selected control group in a study on bleaching reported mild sensitivity which decreased to 6%% after 4 weeks using a placebo gel [ 47].
We also observed a mild sensitivity of cds1Δ cells to nitrogen mustard in our colony counting assay (data not shown).
Clinical manifestations of XP include mild to extreme sensitivity to ultraviolet radiation resulting in inflammation and neoplasia in sun-exposed areas of the skin, mucous membranes, and ocular surfaces.
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