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However, the study also revealed significant gender differences : in women a strong influence of triglycerides, TNFα and decreased HDL-cholesterol, in men only a mild role of BMI and decreased HDL-cholesterol.
The nonessential and fairly mild role of TLSPs in overall meiosis is not surprising, as too much activity of TLSPs during meiosis might lead to high frequency of mutations transmitted to the offspring, which might shift the fine balance from healthy diversity to an unbearable mutation load.
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By contrast, Su z 12 4, slightly enhanced the effect of Su var)2-5 05 suggestheg two two mutations promote each other's effect, indicating a mild positive role of Su z 12 on Ubx.
We found that whereas a short time exposure of 5 minutes of THP-1 macrophages to ghrelin induced Erk activation in a manner partly dependent on EGFR activity, no significant effect of EGFR inhibition was observed with longer treatment periods, such as 15 and 30 minutes (Fig. 3A and data not shown), suggesting a mild and transient role of EGFR in ghrelin responsiveness of macrophages.
We ponder if the protective role of mild elevations, might be true only for patients with hyperbilirubinemia over a much longer time frame that critical patients, which should be studied in future prospective studies.
This may also assist in studying the role of mild environmental factors in the aging process, which might not be easily recognized in short-lived species due to their subtle and gradual cumulative effects.
The neuroprotective role of mild therapeutic hypothermia in traumatic brain injury and TCA survivors remains unclear [ 4, 58, 59].
Our findings are consistent with theoretical models of behaviour change and we have considered the role of mild to moderate psychological distress in this context.
While severe LRI has been linked to development of wheezing or asthma [ 1- 51]51], little is known about the role of mild infection.
In this regard our study suggests a crucial role of mild chronic hypoperfusion in creating such a suitable microenvironment to drive the aggregation of synthetic Aβ1-42.
These findings demonstrate the central role of mild chronic cerebral hypoperfusion in inducing NVU dysfunction, which was sufficient to induce rapid Aβ deposition in brain capillaries in response to systemically-administered Aβ1-42 peptides.
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