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The ULTRA region we tested in this study contains two such elements, but the region only has a mild repressive effect on expression.
Compared to the significant increase on basal LKB1 promoter activity obtained using LKB1Δ-1083, mutatiof of the GAS site had only a mild repressive effect, a change that was not statistically significant.
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This demonstrates that the increase in histone methylation induced by mild folate depletion is not specific to repressive modifications and is probably not directly related to the relatively low level of increased CpG island hypermethylation.
Notably, ATF7IP's repressive partners MBD1 and SETDB1 have very different knockout phenotypes, namely mild spatial learning defects and autoimmune disease in adult mice lacking Mbd1, and early embryonic lethality at 3.5 to 5.5 days post conception for the Setdb1 deletion [ 48- 50].
"Is Kagame repressive?
Most are repressive and unpopular.
Internally, the regime remained repressive.
Egyptian rule was generally repressive.
Both run repressive regimes.
Indian security forces responded with repressive tactics.
"Turkey is a highly repressive country".
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