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Early preclinical studies showed that mild reductions in brain temperature after moderate to severe TBI improved histopathological outcomes and reduced neurological deficits.
Results: Upon initial assessment, the patients had mild reductions in mean blood pressure (MBP) and lack of an increasing heart rate (HR) within 5 min of head up-tilt, an impairment in BP correction during late phase II and reduced phase IV beat-to-beat BP response to the Valsalva maneuver, and reduced heart rate response to deep breathing (HRdb).
Even pharmacological treatment has led, at best, to only mild reductions in hallucinations and delusions.
Mild reductions in platelet counts have also been described.
However, neurocognitive testing suggested only mild reductions in memory efficiency.
Mild reductions in infiltrations were also noted in the brain (data not shown).
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Though there was a mild reduction in glucose excretion in one of the patients, neither transplant was successful.
Ibuprofen was used by two patients; one patient experienced a mild reduction in pain and one did not experience any relieving effect.
A meta-analysis study by Boton et al. revealed that 15%% of 1172 patients on chronic lithium therapy displayed only mild reduction in GFR (Timmer and Sands 1999).
Needed are prospective controlled studies to better understand the effects of a mild reduction in kidney function from kidney donation in otherwise healthy individuals.
True pulmonary parenchymal morbidity is uncommon and when present, persistent restrictive disease is likely related to diaphragmatic weakness with a mild reduction in diffusion capacity (DLCO).
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