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Among them, inhibitor 28 exhibited good dual potency in enzyme inhibitory potency assay (BACE-1: IC50 = 0.567 μM; AChE: IC50 = 1.83 μM), and also showed excellent inhibitory effects on Aβ production of APP transfected HEK293 cells (IC50 = 98.7 nM) and mild protective effect against hydrogen peroxide (H2O2 -induced PC12 cell injury.
None of the CLA-compounds were toxic by themselves, while they showed a mild protective effect on palmitate toxicity in the absence of TO1317 in rat beta cells.
However, ibuprofen may have a mild protective effect in lowering the risk of PD [ 103].
Indeed, why and how age exerts a mild protective effect on specific mortality of colorectal cancer is not clear.
In this model, a mild protective effect of DNase I was observed, with lower anti-single-stranded DNA (ssDNA) and anti-histone antibody levels in transgenic mice compared to littermate controls.
A mild protective effect can be observed at the level of Aβ and BFCNs, in the latter case probably linked to the re-expression of TrkA on these cells, while the increase of phosphotau in AD10 mice is not affected at all by knocking out sortilin.
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Intervention studies with β-carotene, however, have shown no effect on GC risk in low-risk populations (Hennekens et al, 1996), and either no effect (Varis et al, 1998) or mild protective effects in high-risk populations (Blot et al, 1995; Correa et al, 2000).
Smoking (both exsmokers and smokers; OR=0.80 and 0.68, respectively) and frequent contact with noxious substances (OR=0.83) were found to have a mild but significant protective effect on odour recognition/memory (table 2).
Mild weight loss had protective effect on high WC in both genders and MetS in men (RR 0.5, 95% CI 0.26 0.97, P = 0.04).
A comparison of MBL plasma levels in young Gabonese patients suffering severe and mild malaria suggested a protective effect for MBL [ 29].
We also observe an increase in PGC-1α expression during HSC mild uncoupling and a protective effect against cell necrosis and apoptosis in both human and mouse derived HSCs.
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mild beneficial effect
mild hallucinogenic effect
mild inhibitory effect
mild stimulatory effect
mild protective factor
mild negative effect
mild sedative effect
mild estrogenic effect
mild mass effect
mild biomass effect
mild Tyndall effect
mild cytotoxic effect
mild narcotic effect
mild functional effect
mild laxative effect
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