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This is in contrast to the relatively mild phenotypes of knockout mice of other PRC1 members, like Bmi1 [29], Mel18 [30], M33 [31] and MPh1 [32], which exhibit developmental defects that can in part be related to deregulation of Hox genes.
Similar considerations may explain the viability and apparent mild phenotypes of MUL1 mutant flies.
Similar considerations may explain the viability and apparently mild phenotypes of MUL1 mutant flies.
Another discrepancy of our work concerns the mild phenotypes of ND2 mutants relative to other fly and mouse models of complex I deficiency.
Given these results in Drosophila, the relatively mild phenotypes of mice with targeted Pygo1, Pygo2, or double Pygo1/ Pygo2 mutations were striking.
This might select more mild phenotypes of asthma to the DSCG group for the last 12 months of treatment and artificially improve the results of DSCG compared with placebo or low-dose budesonide treatments.
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The relatively mild phenotype of these mice mimics patients with milder PEX7 defects, and highlights the skeleton and lens as sensitive markers of plasmalogen deficiency.
Since we observed only small differences in behavior between Per2−/− and Per2+/+ mice, we expected to observe a mild phenotype of Per1-luc expression in the Per2−/− SCN.
The relatively mild phenotype of P19[Gli/EnR] cells is consistent with previous reports showing that Shh signaling is not essential for the neural tube development [1], [17], [18].
Although the arm mutant phenotypes were not considerably altered by loss of GSK3, the mild phenotype of the armF1a, GSK3 double mutant provided a sensitized background in which we could further assess the role of aPKC in morphogenesis.
It has been suggested that the ability of E-cadherin to compensate for loss of P-cadherin in many tissues may explain the unexpectedly mild phenotype of P-cadherin-deficient mice.
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