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Line 28 had a very mild phenotype with near normal life span, intact cardiac function and normal locomotive activity.
CCR1-/ mice had a mild phenotype with disease presentation and lethality similar to those of WT mice.
The next step in the search for prognostic lipid signatures in plasma is to follow up patients during the development of the disease and to compare the signatures from those who remain with a mild phenotype with those who evolved to a severe one.
Genetic deletion of SAFB2 shows a mild phenotype with no gross structural defects, growth retardation or reproductive defects.
They had a mild phenotype with common features of hypotonia and developmental delay, especially in the area of speech.
Unexpectedly, mcu knockout in the mouse results in a rather mild phenotype with overall size reduction, decreased effort capacities and metabolic alterations, but no major developmental defects.
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The wild type CF2 produced a milder phenotype with this driver (Fig 5H), with the IFM thinner than wild type (Fig. 5I), but intact from anterior to posterior.
Homozygous hypomorphic mice expressing 2% of the Prep1 mRNA have a milder phenotype with embryonic lethality at E17.5 affecting 75% of the homozygous embryos, whereas the remaining 25% homozygous are born and live a normal-length life [10].
The de novo events are predicted to occur at similar frequencies unless there is rearrangement specific selection or ascertainment bias, and, thus, it might be anticipated that both events would be seen in the population with equal frequency unless prenatal lethality, a milder phenotype with less likelihood to be studied or reduced penetrance occurs for the duplication or the deletion.
The mother, with the same deletion, shows a milder phenotype with left eye corneal degeneration as the only sign attributable to MLS.
Mutations in PKD2 predict a milder phenotype with ESRD occurring at a median age of 79 years compared to 58 years in individuals with a PKD1 mutation [ 6].
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