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Lastly, the two MV 2K+1 cases had no clear distinguishing pathological features although they both showed a relatively mild pathology and the lack of a laminar pattern of spongiform degeneration in the cerebral cortex.
Even among ostensibly healthy adults, there is often mild pathology in the kidney.
In this short infection period, both variants caused only mild pathology which is consistent with the results of acute C. jejuni infection of specific-pathogen-free mice [32], and germ-free mice [33].
However, subsequent investigation suggested mild pathology later in life (31).
"-" = no pathology, "+" = mild pathology, "++" = moderate pathology, "+++" = strong pathology.
Predicting progression to disease is most difficult in individuals with early symptoms or mild pathology, but prediction in this population is clinically highly relevant.
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When dealing with a symptom such as anemia, with low predictive value, doctors must confirm non-malignancy before filling outpatient services with mild pathologies [ 13, 14].
For example, Ramsey says, exposure to different viruses may result in milder pathology.
This is consistent with previous reports showing that JNPL3 (BL6) mice display a milder pathology than in a mixed background [ 44].
Interestingly, we observed that a subgroup of the TGF β1 transgenic mice showed more severe muscle weight loss while the rest exhibited milder pathology.
These mice exhibit markers of tau pathology (various phospho-tau epitopes and Alz50) in spinal cord as early as 1 month of age, and milder pathology in cortex by 6 months.
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