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In mouse ESC and at difference from human ESC, SirT1 depletion determines a mild negative effect on pluripotency gene expression.
There is a very mild negative effect on the phenotype of these embryos with the average somite number being 10% lower than untreated embryos.
At 28°C, the S. cerevisiae strains showed no growth inhibition, whereas S. kudriavzevii strains presented a mild negative effect of paromomycin on cell growth.
A seven point scale was used that ranged from a substantial negative effect, a moderate negative effect, to a mild negative effect to no effect to a mild positive effect, a moderate positive effect, to a substantial positive effect.
Ratings were converted into an ordinal scale ranging from 1 to 7 for analysis: substantial negative effect (1), a moderate negative effect (2), a mild negative effect (3), no effect (4), a mild positive effect (5), a moderate positive effect (6), and a substantial positive effect (7).
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Interestingly, when we quantified the overall amount of bacteria positive for LC3B, regardless of the presence of p62, we could see a mild dominant negative effect of p62 oligomerization mutants.
This phenomenon is believed to be associated with both a mild negative inotropic effect and a decrease in systemic vascular resistance, and is especially evident in patients with hypovolemia and compromised cardiovascular status [ 74].
Moreover, those who mentioned that they had experienced mild acute negative effects (e.g. a bad trip) tended to attribute such incidents to accidental factors like a bad pill.
In a control background, we found that both GFP-IQT and the full-length, GFP-HIQT, construct caused spindles to reposition slightly basal, whereas the GFP-HIQCC construct mimicked the Myo10 MO phenotype, causing spindles to move apically, suggesting that it has a mild dominant-negative effect.
Perhaps the very mild winter had a negative effect, or the cold spring, or perhaps the impacts of intensive farming and pesticides are really hitting these common species now".
In addition to their analgesic and sedative effect, opiates decrease the sympathetic discharge associated with the pain of myocardial ischemia and pulmonary edema, and thus exert a mild negative inotropic and chronotropic effect.
More suggestions(15)
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mild beneficial effect
mild preventive effect
mild negative relationship
mild negative behaviour
mild protective effect
mild hallucinogenic effect
mild negative language
mild inhibitory effect
mild stimulatory effect
mild negative event
mild negative correlation
mild sedative effect
mild estrogenic effect
mild negative enhancement
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