Sentence examples for mild mitochondrial defect from inspiring English sources

Mutations in the human PPT1 gene are known to cause the neurodegenerative disease infantile neuronal ceroid lipofuscinosis (INCL) [ 31]. ppt-1 mutants in C. elegans show only a mild mitochondrial defect which is considerably less severe than the human INCL symptoms [ 30].

Thus, cultures of control cell lines and those with mild mitochondrial defects routinely formed synaptically interconnected neural networks.

HtrA2 null mutants are viable but exhibit mild mitochondrial defects, loss of flight and climbing ability, male infertility and sensitivity to oxidative stress and mitochondrial toxins.

They do not report a mitochondrial defect, though the mild nature of the defect observed in our hands and allelic or environmental differences might explain this discrepancy.

Across eukaryotic species, mild mitochondrial stress can have beneficial effects on the lifespan of organisms.

Our findings indicate that ROS inhibition through mitochondrial-targeted antioxidant or mild mitochondrial uncoupling is beneficial for sperm cryopreservation in yellow catfish.

The phenotype is reminiscent of PINK1 and parkin mutants, including a pronounced mitochondrial defect.

Mild mitochondrial dysfunction reportedly has been associated with intelligence, because it can increase activity of the brain's NMDA receptors.

Notably, our previous findings of a primary impairment of apoptotic events and survival defects in HIBM cells, as shown by the lack of activated Akt response to apoptotic stimuli [18], are in line with the mild mitochondrial alterations described here.

Mild muscle-restricted mitochondrial uncoupling had little effect on muscle overall structure, despite reduced mass and mild mitochondrial myopathy (Han and our data not shown).

Hence, mitochondrial depolarization stalls the mitochondrial ETC and promotes mitochondrial defect.