Alternatively, telomere dysfunction may cooperate with mitochondria dysfunction in vivo to induce clearance of dysfunctional cells, thus maintaining a cellular pool with functional mitochondria.
Excessive mitochondria fission events are normally associated with ROS generation and mitochondria dysfunction [32].
Although aging is associated with mitochondria dysfunction, the impact of mitochondria-related aging on CVDs has remained unclear in Taiwan.
Our studies showed that Mn influenced the mitochondria dysfunction and endoplasmic reticulum stress (ER stress).
Gradually researchers are changing their focus from decreased mitochondrial performance to pathogenic signaling elicited by mitochondria dysfunction (Raimundo, 2014).
Neurodegenerative disease such as Alzheimer's disease and Parkinson's disease has been linked to mitochondria dysfunction [22].
The excess influx of Ca2+ eventually leads to mitochondria dysfunction and activation of the caspase-9 intrinsic apoptotic pathway.
The results show that the complex induces apoptosis through ROS-mediated mitochondria dysfunction and inhibition of AKT/mTOR pathways.
Our findings indicated that the complex induced apoptosis in A549 through mitochondria dysfunction and PI3K/AKT/mTOR signaling pathways.
Mitochondria dysfunction and hypoxic microenvironment are hallmarks of cancer cell biology.
