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A day after suffering a mild malaria attack, Lindwall gave a spell of four overs which netted him three wickets, bowling at speeds not seen in Australia since Larwood.
Here we report on a genome-wide linkage study for P. falciparum infection intensity and mild malaria attack among a Senegalese population of children.
Here we report on a genome-wide linkage and association study for P. falciparum infection intensity and mild malaria attack among a Senegalese population of children and young adults from 2 to 18 years old.
We identified three strongly suggestive evidences for linkage: between mild malaria attack and both the 6p25.1 and the 12q22 regions, and between the 20p11q11 region and the prevalence of parasite density in asymptomatic children (PrevPI).
Analyses revealed three strongly suggestive evidences for linkage: between mild malaria attack and both the 6p25.1 and the 12q22 regions (empirical p-value = 5×10−5 and 9×10−5 respectively), and between the 20p11q11 region and the prevalence of parasite density in asymptomatic children (empirical p-value = 1.5×10−4).
Among the clinical presentations of malaria, asymptomatic parasitemia (i.e parasitemia without fever or any clinical sign), and mild malaria attack defined as the association of fever and parasitemia are the most frequent and have very important consequences in term of morbidity and economic effects [7], [8].
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The number of mild malaria attacks ranged from zero to six and 52% of children experienced at least one malaria attack.
Notably, a recent study reported an association with a promoter polymorphism in the NCR3 gene and mild malaria attacks and a haplotype that contained the polymorphism was significantly associated with increased risk of mild malaria [ 32].
Children were considered as suffering from a mild clinical malaria attack when axillary temperature was greater or equal to 37.5°C (or reported history of fever between two systematic surveys) with a PD above 2500 trophozoites/µL.
The total number of mild clinical malaria attacks experienced per children during the active clinical survey was adjusted for predefined covariates using a Poisson regression model.
Mild malaria could have a continuum of degrees of severity.
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