In healthy patients it can cause a primary form of meningoencephalitis (PAM) with a fulminant course in most cases and a mild long-term form in immunocompromised patients called granulomatous meningoencephalitis (GAE) [9, 20, 22].
Atorvastatin administered to patients with normal or mild hypercholesterolemia in the initial year after transplant reduced the initial increase in LDL cholesterol, and, by doing so, prevented the development and progression of coronary artery lesions and endothelial dysfunction with only mild long-term decreases in cholesterol levels.
Few patients experienced mild, long-term sequelae as a result of the extravasation.
In conclusion, in contrast to adults, the majority of survivors of child and adolescent meningioma had no or only mild long-term morbidity.
The majority of survivors of child and adolescent meningioma had no or only mild long-term morbidity, whereas 25% had moderate/severe morbidity, with a significantly increased risk in patients with relapsed disease.
21 Another possibility is that pregnancy is associated with a delay in symptom onset resulting in milder long-term outcome.
Therefore, to minimize the risk of adverse effects whenever possible, the medical community decided to recommend using these drugs in short term, or episodic therapy, in mild cases, and long term, or suppressive therapy, in severe cases.
Although improvement of symptoms can be expected at long term, mild pain may remain.
Chronic CS exposure induced long term mild inflammation with up-regulation of p38 MAPK mRNA in C57BL/6.
There is also a benign form of MS, characterised by few relapses, long periods of remission, and mild activity limitations over the long term [ 4].
For example, although moderate and severe neonatal encephalopathy are associated with development of cerebral palsy and long term morbidity, mild encephalopathy has not been associated with detectable longer term impacts.
