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Laboratory tests showed a severe inflammatory reaction and mild liver function abnormalities.
Three patients had a rash, two had mild liver function changes and three had thrombocytopenia.
These patients presented with headache, myalgia, anemia, and mild liver function abnormalities.
Leukopenia, thrombocytopenia, and mild liver function abnormalities are common and may last 1 3 weeks.
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In this study, only subjects with normal to mild impaired liver function were included as the effect of significant co-existing liver disease on nalbuphine safety and exposure in HD patients is not yet understood.
Neonatal anemia (hematocrit < 50%) was seen in 62% of newborns, with no children needing transfusion; mild elevations of liver function tests, primarily aspartate aminotransferase, were noted in 58% of newborns tested, though none were clinically jaundiced.
Mild elevations in liver function tests occurred in 12.7% with no difference between the treatment groups.
Patients with systemic sclerosis may develop mild abnormalities of liver function tests.
Persistent and relatively mild disturbance in liver function favors nonalcoholic fatty liver disease; transaminase flares are more compatible with glycogenic hepatopathy.
Indeed, in patients with clinical chemistry findings suggestive of mild to moderate liver function impairment [SGOT and/or SGPT > 1.5 × upper limit of normal (ULN), concomitant with alkaline phosphatase > 2.5 × ULN], total body clearance of the drug docetaxel is known to be lowered significantly.
In a few cases mild, reversible elevations of liver function tests have been seen.
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