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Therefore, the question remains whether a mild ischemic event could transform into a full-blown infarct when PACAP's actions are blocked; similar concerns have been raised with the novel CGRP (receptor -antibodies [109, 110].
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Therefore, mechanistically similar mutations, for example, mutation of glial glutamate transporter EAAT2 associated with common migraine [ 115], might render susceptible patients with migraine more prone to develop CSD after mild ischemic vascular events, such as microembolisms, and more sensitive to stroke with mild ischemia [ 114].
A second mild ischemic stroke was defined to result in a moderate to severe ischemic stroke or death and a second moderate stroke in a severe ischemic stroke, reduced life quality, or death [ 13].
But giving it can be dicey in the early stages of a stroke because it can help turn a mild ischemic stroke into a devastating bleeding one.
DOPA CHE is neuroprotective under a mild ischemic condition in rat hippocampus CA1.
Similarly, patients having ischemic events during the first 48 h were not included in the estimation of the risk of ischemic event.
Migraine may directly cause a cerebral ischemic event (migrainous infarction, ICHD-II 1.5.4) [73].
We additionally recorded any ischemic event during the period of observation and asked for any ischemic symptoms at the time of Doppler study.
Ischemic conditioning may be applied before (preconditioning), during (perconditioning) or after (postconditioning) a cerebral ischemic event.
bIncluding sub-arachnoid haemorrhage and massive cerebral ischemic event.
Hypothermia may improve outcome after an ischemic event.
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