Before then, people flowed back and forth across the Rio Grande with only mild interference; a bus even carried maids from Juárez to houses in El Paso.
An adaptive implementation of the filter was shown to converge relatively quickly for mild interference.
The proportion of the little interference zone kept on decreasing, the proportions of the intermediate, severe and very severe interference zones continued increasing, and the proportion of the mild interference zone initially increased and then slightly decreased.
As mentioned before, MND differs from ANI in that the cognitive impairment produces at least mild interference in daily functioning.
These side effects were designated as mild (no interference with daily activities), moderate (some interference with daily activities), or severe (significant, prevented daily activity).
Local adverse events were graded according to specific criteria (NCI Common Toxicity Criteria Version 2.0) Systemic adverse events were graded as mild (no interference with the activities of daily living, no intervention required), moderate (minimal intervention required to increase comfort and to carry out the daily activities) or severe (preventing daily activities).
All adverse events (AEs), including time of onset, end time, intensity, intervention, and outcome, were reported in writing by the investigator to the sponsor based on a patient's toleration of the event as mild (easy to tolerate), moderate (interference with usual activity), or severe (incapacitating or preventing work or usual activities).
Secondary endpoints: headache episodes pain-free at 1 h, headache response at 2 h (mild or no pain), degree of interference with daily activities.
Severity was measured as mild (with no interference of daily activities), moderate (with some interference, but no disruption of daily activities) and severe (with disruption of daily activities) with scores 1-3, and frequency as average number of days per week with abdominal pain/discomfort (0-1/2-3/4-5/> 5) with scores 1-4.
severe: fatal or potentially life threatening or causing permanent disability; moderate: requiring treatment or prolonging stay in hospital or causing interference with normal daily activities; mild: minor reactions that do not require treatment and do not prolong stay in hospital.
