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2. The mild inflammatory responses and transient duration of gene expression noted by Alton and colleagues after single-dose administration of GL67A/pCFTR aerosols to the lungs of patients with CF led to the development of CpG-nucleotide free plasmids containing a synthetic transcriptional regulator consisting of the elongation factor-1α promoter and the human cytomegalovirus (CMV) enhancer.
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To solve this problem, many studies examined the application of chitin, which arouses mild inflammatory response.
Silk protein typically induces a mild inflammatory response that decreases within a few weeks of implantation.
Finally, as implants, the composite material triggered only a mild inflammatory response.
Nevertheless, mammography can also be normal, particularly in patients with dense breasts and/or a mild inflammatory response (Fig. 4).
To solve this problem, many studies examined the application of chitin, acetylated chitosan, which arouse mild inflammatory response.
The biocompatibility was examined in mice indicating a good tolerance upon subcutaneous implantation with only a mild inflammatory response.
This vaccine-induced mild inflammatory response was not accompanied by any changes in mood or cardiovascular activity.
Our data proved that AMP-QDs orchestrated a mild inflammatory response in macrophage, which leads to a low level of immunotoxicity.
The hydrogel degrades completely in vivo in 8 weeks with or without growth factors, eliciting mild inflammatory response but having little impacts on the surrounding tissue.
Another in vivo investigation via subcutaneously implanted PGS films in the same species has shown that PGS has excellent biocompatibility, inducing only a mild inflammatory response (Pomerantseva et al. [2009]).
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