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In this study, the in vivo biocompatibility of albumin nanoparticles was investigated following a single administration of 2, 20, and 390 μg/mouse, showing no inflammatory response (TNF-α and IL-6, cellular infiltration and protein concentration) compared to vehicle controls at the two lower doses, but elevated mononucleocytes and a mild inflammatory effect at the highest dose tested.
In group augmented with cell-seeded scaffold only mild inflammatory effect was noticed.
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Erazo et al. [ 5] showed that their extract had mild anti-inflammatory effect.
An infusion of the leaves of L. hirsuta was found to possess a mild anti-inflammatory effect [ 5].
Naturally occurring triterpenoids, such as ursolic acid, have been found to have mild anti-inflammatory effects [ 18, 27].
In this context, the possibility that the occurrence of a mild inflammatory context determined by increased Treg level could ameliorate immune-mediated pathological effects, as the immune-mediated thrombocytopenia [ 28], appears to be of some relevance.
Most of these effects were driven by JAK inhibition, which completely cleared an initial mild inflammatory response and prevented bone and cartilage erosion.
Unlike a number of in vitro studies employing suspensions of silver nanoparticles, which have shown strong toxic effects, both suspensions and aerosolized nanoparticles caused negligible cytotoxicity and only a mild inflammatory response, in agreement with animal exposures.
The administration of a single dose of etanercept following AMI provides a modest anti-inflammatory effect associated with a mild reduction in basal plasma t-PA activity.
Blood tests showed a mild inflammatory reaction.
Fibrinous exudates, honeycombing and mild inflammatory alveolitis were also present.
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