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The only major toxicity was diarrhea, and other toxicities were mild in both populations.
Toxicity was generally mild in both trials.
Early toxicity was mild in both arms.
Late AEs were very mild in both arms (Table 4).
Adverse events were generally mild in both phase II studies.
Adverse events reported previously were mild in both groups.
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MPIS: Modified Pulmonary Index Score; Values are Mean ± SD, unless indicated The type of asthma presenting with mild acute exacerbation in this study were predominantly intermittent or mild persistent type in both the groups (Table 1).
Cerebellar white matter gliosis was milder
Evaluation of liver histopathology revealed that macro- and microvesicular steatosis, lipogranulomas, and perisinusoidal fibrosis were significantly milder in both ELE and BLE groups than in the FG group.
Blood work revealed leukocytosis, erythropenia, lymphocytosis, thrombocytopenia, coagulation abnormalities, but all to a mild extent, together with mild elevation in both alanine aminotranferease (ALT) and alkaline phosphatase (ALKP), and a mild decreased in glucose.
Of those with mild NPDR, five had mild findings in both eyes, one had involvement of a single eye, and another had very mild NPDR in the second eye.
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