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In this tissue, ductal morphology and branching are normal, but there is mild hyperplasia of the luminal cell compartment [26].
This effect was accompanied by mild hyperplasia of vaginal epithelium.
Synovial necrosis was not identified in these pre-operative groups, although mild hyperplasia of the lining layer was observed.
There was also mild hyperplasia of the synovial lining, but without any evidence of inflammatory cells being observed (Fig. 5A,5B).
Histologic examination of infected frogs on which necropsies were performed since the 1999 epidemic shows focal mild hyperplasia of the superficial epidermis associated with sporangia of B. dendrobatidis.
In experimental animals prolonged treatment with toxic doses of cyclosporin A leads to interstitial fibrosis and tubular atrophy with mild hyperplasia of the juxtaglomerular apparatus that has been attributed to ischemia [ 12].
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These BK5.ATF3 mice exhibit several epidermal phenotypes, including a gross hyperplasia of the outer root sheath cells of the hair follicles, resulting in abnormal hair growth, and a milder hyperplasia of the interfollicular epidermis [ 19].
AID+/− mice express roughly 50% of normal AID levels, and display a mild hyperplasia, reminiscent of AID deficient mice and humans.
Nonetheless, genetic ablation of Krt76 in mice results in skin barrier defects, epidermal hyperproliferation and inflammation12,13, with mild hyperplasia and keratinisation of the buccal epithelium10.
Fourteen days p.i. normal architecture of the lung was restored in animals from these groups, apart from some residual peribronchiolar lymphocytic infiltrate and mild hyperplasia and hypertrophy of the bronchiolar and alveolar epithelium, consistent with regeneration.
All joints injected with IA showed signs of mild hyperplasia, and this was not different in OVX and sham animals.
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