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These properties may make the active place avoidance task exquisitely sensitive to even mild hippocampal dysfunction [40], [41], certainly more than the water maze [39], [42], and possibly more than other place learning tasks.
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Such amnesia is typical in disorders that involve hippocampal dysfunction.
The discrete-trial rewarded alternation T-maze task is highly sensitive to hippocampal dysfunction.
Memory deficits associated with hippocampal dysfunction are a key feature of a number of neurodegenerative and psychiatric disorders.
Others have suggested that hippocampal dysfunction might account for disturbances in long-term memory frequently observed in people with schizophrenia.
Indeed, hyperactivity and additional sensorimotor abnormalities have been linked to hippocampal dysfunction [31].
Decreased hippocampal volumes and hippocampal dysfunction are associated with psychological disorders with strong affective components such as post-traumatic stress syndrome, bipolar disorder and depression [34].
Hippocampal dysfunction (s) have been reported in aggressive behaviors [18], and in particularly in relation to early environmental adversity [63].
In his seminal review in 1991, Delong conceived of autism as a 'developmental syndrome of hippocampal dysfunction' [60].
These clinical features are typically associated with hippocampal dysfunction.
By contrast, hippocampal volumetry showed mild hippocampal atrophy in three patients (two bilaterally and one on left side).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com