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Common allelic variants with a mild functional effect can influence the risk for sporadic disease.
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Seven additional variants in other genes had SIFT scores of less than 0.15 and may have mild functional effects (Table 2).
The majority of complex disease variants were annotated by the bottom fifteen consequences categories, suggesting milder functional effect of complex disease variants compared to other three types of disease variants.
For example, when most participants possess similarly mild functional limitation characteristics, the scale may have a significant floor effect.
Large floor effects and the suboptimal response distribution of most items, however, suggested that the PDI is insensitive to mild functional limitation.
Genetic polymorphisms with a documented functional effect on blood coagulation proteins may represent a useful tool, by reflecting the individual's lifelong exposure to even a mild prothrombotic state.
The patient with the c.436C>T had mild functional disability.
An increase in mild functional decline was more prevalent than severe functional decline.
Thus, atRA-induced iTregs were not only resistant to the inhibitory effects of IL-1β and IL-6, but these proinflammatory cytokines appeared to have a mild positive effect in stabilizing their phenotype and functional activity.
This adds further evidence that c.101T>C is a mild but functional variant with the effect larger in the c.35delG group.
Chewing the leaf produces a mild stimulant effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com