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An increase in mild functional decline was more prevalent than severe functional decline.
Mild functional decline as measured by the Clinical Dementia Rating scale was observed in only one subject at the time of evaluation.
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Conclusion A comprehensive specific care plan in memory clinics had no additional positive effect on functional decline in patients with mild to moderate Alzheimer's disease.
APOE ε4 carrier status influences the rate of progression of both cognitive and functional decline in patients with mild cognitive impairment and prodromal AD [ 27, 28].
Objective To test the effectiveness of a comprehensive specific care plan in decreasing the rate of functional decline in patients with mild to moderate Alzheimer's disease compared with usual care in memory clinics.
Lung cystic involvement correlates with lung function abnormalities and predicts functional decline.
When first observed in 1996, 1560 (85%%) of these elders had no functional decline, 180 (10%%) showed a mild level of disability, and 98(5%) showed severe disability.
In a Cox model comparing severe with mild changes and adjusted for clinical factors of functional decline, the risk of transition to disability or death was more than twofold higher (hazard ratio 2.36, 95% confidence interval 1.65 to 3.81).
Preventive strategies for frailty and mild cognitive impairment (MCI) are important for avoiding future functional decline and dementia in older adults.
Mdx mice exhibit a mild pathology with a slightly reduced lifespan (18 24 months) and functional decline of hindlimb muscles becoming evident at approximately 18 months of age [ 4], which is most likely a result of modifier genes in the C57BL/10 strain that can alter the effect of dystrophin loss on skeletal muscle pathology.
We carried out a cluster randomised trial at national level to test the effectiveness of a comprehensive specific care plan in decreasing the rate of functional decline in community dwelling patients with mild to moderate Alzheimer's disease compared with usual care in memory clinics.
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