At 45 min post injection (p.i ., the mean radioactivity ratio of the liver to heart (MRAR) could distinguish among rats with normal, mild fibrotic (TAA treatment for 3 weeks), or advanced fibrotic (TAA treatment for 9 weeks) liver (Fig. 2).
Because of its early expression by T cells, LIGHT may be an initiator of fibrotic diseases, but other sources in the immune system could also signify a role for LIGHT in maintaining or perpetuating fibrotic activity.
Thus, we could speculate that the angiogenic activity in our model could be inhibited by L-NAME, and that only the fibrotic activity would persist.
There was less disruption of the hepatic cellular structure with mild fibrotic septa.
Fibrotic activity and nuclear dysplastic findings remained almost the same.
The chitinase-like protein, Chi3L1, is associated with increased fibrotic activity as well as inflammatory processes.
The increase of TNC in interstitial areas of fibrotic activity could play a key role in the altered wound healing.
Indeed, the transfer of enriched B or T cells increased autoantibody production but did not cause skin fibrosis, and transfer of T and B lymphocytes led only to mild fibrotic lesions compared with massive fibrosis in Tsk-1 mice [ 31].
