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These data suggest that ionic contrast media are more likely than nonionic contrast agents to cause mild exacerbation of renal insufficiency when given intravenously.
Overall, given the absence of cellular respiratory/energy disturbances and histopathological damage as well as the relatively mild exacerbation of organ injury/dysfunction (as measured by selected circulating parameters), this study strongly cautions against reflexive interpretation of organ deregulation as the main culprit of early deaths in the young outbred CLP female mice.
Cranial computed tomography images showed mild exacerbation of hydrocephalus.
More importantly, knocking out the expression of gelsolin, an actin-binding protein with filament-severing properties found downregulated in RA, resulted in mild exacerbation of the arthritic phenotype.
At week 8, patient CD1 had a mild exacerbation of disease which appeared to be associated with an increase in Ruminococcaceae, Lachnospiraceae, and Peptostreptococcaceae.
We did not register progression of bacterial infection in those cases with the exception of one 10-month patient with mild exacerbation of bronchitis.
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That meta-analysis also included studies conducted in patients who had milder exacerbations of COPD.
In case of a mild exacerbation, 43% of GPs took into account disease severity by giving a higher total dose of prednisolone to patients with severe and very severe COPD: on average 116 mg prednisolone per treatment regime more (P < 0.001).
Three of the five patients (CD1, CD2, and CD5) experienced a mild exacerbation or recurrence of the disease after the conclusion of EEN therapy and were commenced on medical therapies.
Another Spanish study revealed that the cost of a moderate asthma exacerbation was 4-fold greater than that of a mild exacerbation, and the cost of a severe exacerbation as much as 12 times that of a mild exacerbation.
One patient (CD4) experienced a mild exacerbation at week 16 of the 26-week period of observation, however, he was again in remission by week 20.
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