The intra-venous administration of pharmacological doses of oleoyl-estrone causes mild estrogenic effects, and results in high circulating levels of estrone [ 9].
Similarly, PBDE has mild estrogenic effects in mice (Mercado-Feliciano and Bigsby 2008a), and these effects are likely caused by HO-PBDEs that act as ligands for the estrogen receptor (Mercado-Feliciano and Bigsby 2008b).
Tibolone, as a tissue-specific steroid, does not have an estrogenic effect on breast cells.
Our results point to an additive estrogenic effect in a CA model for parabens.
Figure 4A shows that CNT had no estrogenic effect in the range of 3.13 to 50 mg CNT/L.
Further analyses suggested that BDE47 and BDE154 have an estrogenic effect in male fish.
Such correlation suggests an estrogenic effect of SWT.
Again, we used the uterus weights as a PD marker for the classic estrogenic effect.
The estrogenic effect was subsequently evaluated in SUR2KO and WT female mice using ovariectomized models.
