There are a number of different forms of obesity-related CKD, with the majority of cases associated with microalbuminuria, endothelial dysfunction, and mild-to-moderate decrease in GFR, mainly associated with cardiovascular risk.
Atorvastatin administered to patients with normal or mild hypercholesterolemia in the initial year after transplant reduced the initial increase in LDL cholesterol, and, by doing so, prevented the development and progression of coronary artery lesions and endothelial dysfunction with only mild long-term decreases in cholesterol levels.
Initially, an undetermined triggering event causes mild oxidative stress, coinciding with perivascular inflammation and endothelial dysfunction.
The clinical implication of this study is the demonstration of beneficial effects of both sitagliptin and voglibose on endothelial dysfunction in low-risk and mild-risk patients with type 2 diabetes.
Indeed, in one trial, the inhibition of xanthine-oxidase with allopurinol was shown to improve endothelial dysfunction in patients with type 2 diabetes with mild hypertension [ 153].
In some animal models, even mild elevation in uric acid levels has been reported to induce endothelial dysfunction and inflammatory cytokines, while other animal studies have shown the opposite.
In addition, the majority of our participants had mild hyperuricemia and we cannot exclude a relation between severe hyperuricemia and endothelial dysfunction in healthy adults based on our results.
To compare the short-term effects of rosuvastatin and simvastatin on insulin-resistance and endothelial dysfunction in middle-aged patients with type 2 diabetes and mild untreated dyslipidemia.
FMD and flicker-induced vasodilatation were measured in healthy volunteers and in different groups of patients with known endothelial dysfunction, namely patients with type 1 diabetes and patients with mild systemic hypertension and/or hypercholesterolemia.
