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Heterocycle optimization and template modification lead to the identification of compound 24 which demonstrated increased atrial effective refractory period in the rabbit pharmacodynamic model with mild effects on blood pressure and heart rate.
Co-author Dr Thomas Sussan, also from Johns Hopkins, said: "E-cigarette vapour alone produced mild effects on the lungs, including inflammation and protein damage.
The recent H1N1 flu strain, which has raised fears worldwide despite having had relatively mild effects on most people so far, is turning upside down traditional health concerns at agricultural exhibitions and state and county fairs around the country.
Litter characteristics only showed mild effects on SOC accumulation.
Temperature and SO2 concentration had mild effects on the initial conversion rate and negligible effects on the ultimate conversion.
Although oil and natural gas prices have risen sharply, they will likely have only mild effects on overall economic activity, says the Dallas Fed.
We find these parameters have significant effects on the stability of magnetic towers, but mild effects on the stability of hydro jets.
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The predictions themselves could have a mild effect on markets.
A short strike against Chrysler this week would have only a mild effect on the company's production.
About the age when a child's voice stops cracking, education itself has a relatively mild effect on academic success.
Among these operating parameters, pressure and temperature were found to have only mild effect on the product.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com