Other body organs had only mild amyloid deposition.
Seven cases showed moderate-severe, 5 mild amyloid deposition.
The arterioles showed mild hyaline deposition; the arteries were unremarkable.
Very mild PrPSc deposition in the cerebellum correlated well with apparent lack of the severe motor dysfunctions typical for 263K.
CreLysM Casp8fl/fl mice failed to develop glomerulonephritis (Fig. 1e, f), although mild IgG deposition in the kidney (Fig. 1e) and higher proteinuria levels (Fig. 1g) were detected compared with control mice.
This mutation is responsible for a GSS syndrome characterized by mild amyloid PrP deposition in patients [29], [30].
Interestingly, neuro-pathological examination of CNS of patients with this disorder showed mild amyloid PrP deposition, and the disease presented reduced penetrance among relatives [29], [30].
Class 2 biopsy cases showed mild mesangial amyloid deposition (10-25% of tuft involved).
Skin lesions were mostly characterized by mild to moderate deposition of amorphous granular calcium material, positive to Von Kossa stain, and by mild to moderate inflammations composed mostly of macrophages, lymphocytes, and few giant cells.
In the original case series of nine patients reported by Brodsky et al. on warfarin-related nephropathy, five patients had mild glomerular immune deposition (of which three were IgA on immunofluorescence) and one had focal segmental glomerulosclerosis.
