Sentence examples for mild depolarization of from inspiring English sources

Mild depolarization of the mitochondrial potential by PBE does not involve the constituent catechin as revealed in the present study.

The extract's inhibition of ACE (IC50 = 51.30 ± 5.1 μg/mL) and mild depolarization of isolated liver mitochondria membrane potential were concentration-dependent.

Consistent with this model, we find that lanosterol induces mild depolarization of mitochondria and promotes autophagy.

Measurement by safranine fluorescence however showed that the mild depolarization of the ΔΨ m by PBE was independent of catechin.

The neuroprotective effect of a plant extract was once attributed to the mild depolarization of ΔΨ m [ 59].

Previous work showed that mild depolarization of cortical astrocytes cultured from adult, but not neonatal, rats caused NCX to operate in the reverse mode leading to [Ca2+]cyt increases and consequential exocytotic glutamate release (Paluzzi et al., 2007).

Such mild depolarization has been attributed to the neuroprotective effect of a plant extract [42] and the protection of cardiomyocytes from oxidative stress [40].

This 'slippage' in coupling relaxes the obligatory gating by voltage, increasing the probability of transitioning from C into C′ at mild depolarization (Shin et al., 2004).

Similarly, mild depolarization, due to an increase in extracellular K+ (15 and 35 mM), of cortical astrocytes cultured from adult, but not neonatal, rats caused NCX to operate in the reverse mode and generated [Ca2+]cyt increases which triggered release of glutamate (Paluzzi et al., 2007); these effects were blocked by KB-R7943 implicatheg the reverse mode of NCXs.

In support of this notion, NE at 1 μM only yielded a mild depolarization, estimated at < 5 mV (Fig  1A; Supplementary Fig 1B).

Agents that are known to trigger mild depolarization include those that open the mitochondrial ATP-sensitive potassium channel (mitoKATP), such as diazoxide [ 4]; induction of uncoupling proteins [ 5– 7]; volatile anesthetics, which act on BKCa [ 8]; low-dose FCCP [ 9]; and interventions which trigger flickering of the mPTP such as ischemic preconditioning [ 10].