FKRP dystroglycanopathy affects respiratory and cardiac muscles even in diseases with mild defects in skeletal muscles.
Moreover, the OPAO plants exhibited mild defects in mature leaves beginning at the early reproductive stage in the paddy field.
Mild defects include loose and defasciculated connectives, wavy in appearance.
Since we find this hard to believe, we tested whether there might be more mild defects in the mutant flies.
smpA mutants are viable and are reported to have only mild defects in their outer membrane [39].
Mild defects include irregularly spacing of the ventral nerve cord, some disorganization of the axon scaffold, abnormally thin or thick, and wavy longitudinal connectives.
In Drosophila, zygotic loss-of-function mutants of abl display mild defects in the axon scaffold including ectopic midline crossing errors [40], [41], [49].
APP knock-out mice are viable and fertile and have mild defects in locomotor activity, forelimb grip strength, behavior and long term potentiation (LTP) [2], [3], [4], [5].
In mild defects, morpholino-injected embryos showed delayed development, shorter and curled trunk and tail compared to wild-type or to control MO-injected embryos (Fig. 2D-b).
Therefore, in order to not overlook more mild defects, we tested whether phosphorylation of the Tsc1/2 complex by Akt might affect organismal metabolism by measuring animal lipid levels.
Treatment of wild-type controls with rapamycin produced only mild defects in the lamina plexus (Figure 7D, Table 1) supporting the hypothesis that Tsc1-mediated regulation of axon guidance operates largely via a rapamycin-insensitive function of Tor.
