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Moreover, they showed mild cytotoxic effect (IC50 = 183.8 μM & 172.04 μM, respectively) in normal breast cells 184A1.
The silver aerosol caused a mild cytotoxic effect observed by increased LDH release.
The hexane extract displayed a mild cytotoxic effect on both A549 and NCI-H1299 human lung carcinoma cell lines.
The ethyl acetate of P. macrocarpa seeds exhibited mild cytotoxic effect against HepG2 cells (IC50 values between 30 and 60 μg/mL) [ 46].
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The water extract showed no cytotoxic effect against all selected cancer cell lines with IC50>100 μg/mL and exhibited a mild cytotoxic effects against MRC-5 cells.
In addition, the other compounds G and C showed mild cytotoxic effects with IC50's ranging from 17.5 to 69.1 μg/mL.
BIX-01294 was found to produce mild cytotoxic effects in MEFs treated at 2.0 μM based on morphological assessment and evaluation of cell growth (RGR) by MTT assays.
As shown in our in vitro study, proliferation of all three NSCLC cell lines was inhibited when low MOI AdTRAIL was combined with EGFR inhibitors, even at low concentrations at which the inhibitors had light to mild cytotoxic effects.
The results obtained herein show that treating IEC6 and HaCaT cells with low concentrations of leaf extracts prepared from any of the 12 Rhododendron species exhibited rather mild or no cytotoxic effects, whereas the use of high concentrations (500 μg/mL) resulted in a rather expected and remarkable cytotoxicity.
We previously reported that combined treatment with melphalan and mild hyperthermia (1 h at 42 degrees C) caused a synergistic cytotoxic effect in JR8 melanoma cells, paralleled by a stabilisation of a melphalan-induced G2-phase cell block.
It is estimated that only one-fourth of administered chemotherapy drugs have their intentional cytotoxic effect.
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