They rapidly develop progressive and severe neurological deterioration causing hyperactivity, sleep disorders, loss of speech accompanied by behavioral abnormalities, neuropsychiatric problems, mental retardation, hearing loss, and visceral manifestations, such as mild hepatomegaly, mild dysostosis multiplex, mild coarse facies, and hypertrichosis [2], [3].
Significant findings included edematous conjunctivae with mild hemorrhage; nasopharyngeal bleeding; coarse breath sounds; large ecchymoses at venipuncture sites; scattered petechiae on the trunk, arms, and upper thighs; extensive edema of the extremities and scrotum; and melena on rectal examination.
For example, gait speed a highly recommended indicator of mobility would be recoded to the coarse qualifier: no problem, mild problem, etc.
Coarse CAP exposure produces a mild physiologic response in healthy young volunteers approximately 20 hr postexposure.
In addition to cognitive deficits, the FXS phenotype includes mild dysmorphic features (large everted ears and coarse elongated face) and macroorchidism established around puberty.
Unfortunately, delays to or missed diagnosis are common especially related to patients with mild form since they may present without a typical coarse facies and with less pronounced skeletal disease.
In the BAL fraction we observed a statistically significant 10.7% increase in percent PMNs per 10 μg/m of coarse PM (p = 0.0065), indicative of mild pulmonary inflammation.
The results of this study showed that young, healthy people experience mild acute physiologic effects when exposed to environmentally relevant coarse air pollution PM.
Grilled wild Canadian salmon had the dense flesh of a fish that had swum freely, but coarse black pepper distracted from the salmon's mild flavor.
Biomicroscopy typically revealed the classic microsporidial corneal infection— coarse, multifocal, granular punctuate epithelial keratitis, along with mild follicular or papillary conjunctivitis.
Acquario's fresh sardines, grilled and sprinkled with coarse salt, have a strong, briny aroma but a mild, wonderfully nutty flavor; they are served with a small green salad.
