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In the absence of IL-1β, both n-3 compounds induced a mild catabolic response with increased loss of sGAG, particularly at 10 μM.
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Burn induces a sustained catabolic response which causes massive loss of muscle mass after injury.
This effect is also seen in human clinical practice and is the result of several factors, including anorexia and a catabolic response to cytotoxic drugs.
Osteoblasts perceive and respond to changes in their pericellular environment, including biophysical signals and oxygen availability, to elicit an anabolic or catabolic response.
These findings provide evidence of clinically relevant, age-dependent differences in the response of the knee to meniscal tears, with elevated expression of arthritis-related markers, indicative of an increased catabolic response, in patients under 40 years of age.
Both colon (COLO205) and liver (HepG2) cancer cell lines demonstrate a more diverse catabolic response, with more wells showing a strong reductive response (Figure 1E G).
The intestinal tract plays a central role in the protein catabolic response after injury and infection.
It is recognized that administration of insulin with glucose decreases catabolic response in sepsis.
The catabolic response was not further influenced with the PKGII inhibitor in IL-1β-treated constructs.
These data suggest that SOCS1 effectively modulates the catabolic response of chondrocytes to IL-1β.
Thus, pharmacologic inhibitors selective for PDE subtypes may reduce the catabolic response in chondrocytes.
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