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We therefore conclude that the relatively mild bone phenotype we describe in the caspase-7 knock-outs was not due to compensation by caspase-3.
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We were initially disappointed to find that decreased expression of this factor led only to a very mild immune phenotype, but we later realised that mutant mice lacking Scnhurri-3 display a very striking bone phenotype of extremely elevated bone mass.
We, therefore, analyzed the bone phenotype of Maged1-deficient mice.
There was a mild bone activity on the condyle head in the three-phase bone scan.
Mild bone abnormalities were frequently observed, including changes of shape and contour of bone surface, and sclerosis of bone marrow.
In the area from the left leg to the foot, plain X-rays revealed mild bone atrophy and magnetic resonance imaging (MRI) revealed mild bone and muscle atrophy.
How can we explain the bone phenotype of Lrp4ECD mice?
This indicates that the bone phenotype occurs independently from the cartilage phenotype.
The bone phenotype also varies between subtypes.
The MMP2-/ mice have a complex bone phenotype that includes reduced bone volume in the long bones.
Supplementary Table 1 List of genes associated to bone phenotypes.
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