The only currently existing management for sarcopenia consists of nutritional supplementation and an exercise regimen, albeit with only mild beneficial effects.
Mild hypothermia has a beneficial effect on outcome in patients after out of hospital cardiac arrest [ 1- 3].
Clinical data are very limited, but a double-blind controlled trial conducted in 41 normotensive type I or II diabetes patients with mild neuropathy suggested a beneficial effect of the ACEI trandolapril on peripheral neuropathy [ 14].
However, while cART reduced the incidence 6 of severe cases of HAND (HIV-associated dementia [HAD]) and ameliorated some cognitive difficulties, 7, 8 it has not had a clearly beneficial effect on milder forms of HAND, including mild neurocognitive disorder (MND) and asymptomatic neurocognitive impairment (ANI), which are now more prevalent than HAD 1.
Moreover, acetylcholinesterase inhibitors (AChEI) may have a beneficial effect on mild and moderate psychosis.
Recent experiments have demonstrated the beneficial effect of mild moisture exposure on film growth,[ 26] and it was suggested that (partial) decomposition of OIHPs as a result of water may trigger a proton-migration process.[ 27] Furthermore, the organic cation could be deprotonated, thus indicating a possible intrinsic source of migrating hydrogen.
While further global transcriptomic and proteomic profiling, carried out during and at different times after bout of exercise, may help to better understand the molecular mechanisms underlying the beneficial effect of mild exercise training, the present results clearly show a link between the long lasting expression of some exercise training-induced genes and cardioprotection.
The role of hypoxia in inflammatory lesions of both MS and EAE may be compound, since chronic mild hypoxia (10% O2) has a beneficial effect in the acute and chronic phases in MOG-induced mousEAEAE [ 171].
Since two prospective randomized multicenter trials demonstrated a beneficial effect of induced mild hypothermia on neurological outcome after cardiac arrest [ 1, 2], one could argue that patients with spontaneous hypothermia on ICU admission might have a better outcome, since the time needed to reach the target body temperature during induced mild hypothermia is reduced.
